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>> H-index: 24 (Google Scholar)

  Guest Editor, Current Pharmaceutical Biotechnology, Thematic issue “Miniaturized platforms & methods for pharmaceutical studies”. 
* One of the most cited issues. 
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63. Wei, X.; Zhou, W.; Sanjay, S. T.; Zhang, J.; Jin, Q.; Dominguez, D. C.; Li, X.* Multiplexed Instrument-free Bar-chart SpinChip Integrated with Nanoparticle-mediated Magnetic Aptasensors for Visual Quantitative Detection of Multiple Pathogens, Anal Chem 2018, 90, 9888-9896. DOI: 10.1021/acs.analchem.8b02055.     Full Text

Jin, Q.; Shen, Y.;* Ma, L.; Zhu, S.; Zhang, J.; Zhou, W.; Wei, X.; Li, X.* Novel TiO2 catalyst carriers with high thermostability for selective catalytic reduction of NO by NH3, Catalysis Today 2018, In Press. DOI: 10.1016/j.cattod.2018.04.038. (2016 IF 4.6)


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Fu, G.; Sanjay, S. T.; Zhou, W.; Brekken, R.A.; Kirken, R.A.; Li, X.* Exploration of Nanoparticle-Mediated Photothermal Effect of TMB-H2O2 Colorimetric System and Its Application in a Visual Quantitative Photothermal Immunoassay, Anal Chem 2018, 90, 5930-5937. DOI: 10.1021/acs.analchem.8b00842. (IF 6.3) 

-Highlighted by X-MOL,  or check the local file


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Katla, S.K.; Zhang, J.; Castro, E.; Bernal, R. A.; Li, X.* Atomically-precise Au25(SG)18 nanoclusters: Rapid single-step synthesis and application in photothermal therapy, ACS Appl. Mater. Interfaces 2018, 10(1), 75-82. DOI: 10.1021/acsami.7b12614. (Impact Factor in 2016, 7.5)

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Sanjay, S. T.;+ Zhou, W.;+ Dou, M.;+ Tavakoli, H.; Ma, L.; Xu, F.; Li, X.* Recent Advances of Controlled Drug Delivery Using Microfluidic Platforms, Adv. Drug Deliv. Rev. 2018, 128, 3-28. DOI: 10.1016/j.addr.2017.09.013. (Impact factor in 2015, 15.16; 5-year IF, 17.6 ).

  • +: Contribute equally.


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57. Dou, M.; Sanjay, S. T.; Li, X. J.* MULTIPLEX QUANTITATIVE LAMP DETECTION ON A PMMA/PAPER HYBRID SPINCHIP, Proc.  Micro Total Analysis Systems 2017, 21, 1227-1228.
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56. Tang, R.; Yang, H.; Choi, J. R.; Gong, Y.; You, M.; Wen, T.; Li, A.; Li, X.; Xu, B.; Zhang, S., et al. Capillary blood for point-of-care testing, Crit. Rev. Clin. Lab. Sci. 2017, 54, 294-308. DOI: 10.1080/10408363.10402017.11343796. (2016 IF 5.3)
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Dou, M.; Sanjay, S. T.; Dominguez, D. C.; Zhan, S.; Li, X.* A Paper/Polymer Hybrid CD-Like Microfluidic SpinChip Integrated with DNA-Functionalized Graphene Oxide Nanosensors for multiplex qLAMP Detection, Chem Comm 2017, 53, 10886-10889. DOI: 10.1039/C1037CC03246C (2016 IF 6.3)
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Tang, R.; Yang, H.; Choi, J. R.; Gong, Y.; Hu, J.; Wen, T.; Li, X.; Xu, B.; Mei, Q.; Xu, F. Paper-based device with on-chip reagent storage for rapid extraction of DNA from biological samples, Microchimica Acta 2017, 184, 2141-2150. DOI:10.1007/s00604-017-2225-0
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Tang, R.; Yang, H.; Gong, Y.; Liu, Z.; Li, X.; Wen, T.; Qu, Z.; Zhang, S.; Mei, Q.; Xu, F. Improved Analytical Sensitivity of Lateral Flow Assay using Sponge for HBV Nucleic Acid Detection, Sci. Rep. 2017, 7, 1360. DOI:10.1038/s41598-017-01558-x. (2016 IF 4.3)
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Shen, F.*; Li, Y.; Liu, Z.; Li, X*. Study of flow behaviors of droplet merging and splitting in microchannels using Micro-PIV measurementMicrofluid Nanofluid 2017, 21, 66. DOI: 10.1007/s10404-017-1902-y

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Zhang, J.; Wei, X.; Zeng, R.; Xu, F.; Li, X.* Stem cell culture and differentiation in microfluidic devices towards organ-on-a-chip,  Future Sci OA 2017, 3(2), FSO187. DOI: 10.4155/fsoa-2016-0091.
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Zhan, S.*; Zhang, Y.; Shi, Q.; Li, X.* Efficient NH3-SCR removal of NOx with highly ordered mesoporous WO3(x)-CeO2 at low temperatures, Appl. Catal. B: Environmental. 2017, 203, 199-209. (Impact Factor in 2016, 9.45)
- Highly Cited Paper (Web of Sciences 08/2018)
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Dou, M.; Sanjay, S. T.; Dominguez, D. C.; Liu, P.; Xu, F., Li, X.* Multiplexed Instrument-Free Meningitis Diagnosis on a Polymer/Paper Hybrid Microfluidic Biochip, Biosens. Bioelectron. 2017, 87, 865-873.  DOI: 10.1016/j.bios.2016.09.033. (Impact Factor in 2016, 7.8)

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Zhang, Q.; Ouellet, H.; D., W.; Jiang, G.; Liu, W., Li, X.; Qian, W.; Sun, J., EsxA membrane-permeabilizing activity plays a key role in mycobacterial cytosolic translocation and virulence: effects of single mutation at glutamine 5, Sci. Rep. 2016, 6, 32618. (2016 IF 4.3)

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Dou, M.; Sanjay, S. T.; Li, X. J.* A polymer/paper hybrid microfluidic device for multiplexed instrument-free detection of bacterial meningitis, Proc.  Micro Total Analysis Systems 2016, 20, 607-608.
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Sanjay, S. T.; Dou, M.; Sun, J.; Li, X.* A paper/polymer hybrid microfluidic microplate for rapid quantitative detection of multiple disease biomarkers, Sci. Rep. 2016, 6, 30474. DOI: 10.1038/srep30474(2016 IF 4.3)

  • Received about 10000 views within two months of its publications. 

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Dou, M.;+ Lopez, J.;+ Rios, M.;+ Garcia, O.; Xiao, C.; Eastman, M.; Li, X.,* A fully battery-powered inexpensive spectrophotometric system for high-sensitivity point-of-care analysis on a microfluidic chip, Analyst 2016, 141, 3898-3903. (Invited for the Analyst Emerging Investigator themed issue).
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Fu, G.; Sanjay, S. T.; Li, X*. Cost-effective and sensitive colorimetric immunosensing using an iron oxide-to-Prussian blue nanoparticles conversion strategy, Analyst 2016, 141, 3883-3889. (Invited for the Analyst Emerging Investigator themed issue ).
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43. Sanjay, S.T.; Dou, M.; Fu, G.; Xu, F.; Li, X*. Controlled Drug Delivery Using Microdevices. Curr Pharm Biotechnol 2016, 17, 772-787.   Full Text

Fu, G.; Sanjay, S.T.; Dou, M.; Li, X*. "Nanoparticle-mediated photothermal effect enables a new method for quantitative biochemical analysis using a thermometer", Nanoscale 2016, 8, 5422-5427. (Impact Factor in 2016, 7.4)

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Dou, M.; Garcia, J. M.; Zhan, S.; Li, X*. Interfacial nano-biosensing in microfluidic droplets for high-sensitivity detection of low-solubility molecules. Chem Comm 2016, 52, 3470-3473.  (inside Front Cover) (2016 IF 6.3)

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Choi, J. R.; Hu, J.; Tang, R. h.; Gong, Y.; Feng, S.; Ren, H.; Wen, T.; Li, X.; Wan Abas, W. A. B.; Pingguan-Murphy, B.; Xu, F. An Integrated Paper-based Sample-to-Answer Biosensor for Nucleic Acid Testing at the Point of Care. Lab  Chip 2016, 16, 611-621. DOI: 10.1039/C5LC01388G.
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Qi, H.; Huang, G.; Han, Y. L.; Wang, L.; Li, X. J., Wang, S.; Lu, T.J.;Xu, F.. In vitro spatially organizing the differentiation in individual multicellular stem cell aggregatesCrit Rev Biotech 2016, 36(1): 20-31. (2016 IF 6.5)
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38. Sanjay, S. T.; Dou, M.; Li, X. J.* A paper/PMMA hybrid microfluidic microplate for detection of infectious diseases. Proc.  Micro Total Analysis Systems 2015, 19, 951-953.   Full Text
Sanjay, S. T.; Fu, G.; Dou, M.; Xu, F.; Liu, R.; Qi, H.; Li, X.*  "Biomarker detection for disease diagnosis using cost-effective microfluidic platformsAnalyst 2015, 140, 7062-7081, DOI: 10.1039/C5AN00780A .   (Front Cover)

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M. Dou, S. T. Sanjay, M. Benhabib, F. Xu and X. Li*, Low-cost Bioanalysis on Paper-based & Its Hybrid Microfluidic Platforms,  Talanta, 2015, 145, 43-54. (Invited) (2016 IF 4.3)


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35. M. Dou, D. C. Dominguez and X. Li*," A Versatile Paper /PDMS Hybrid Microfluidic biochip for low-cost global Infectious Disease Diagnosis", Proc.  Micro Total Analysis Systems, 2014, 18, 1048-1050.
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Xu, X., Akay, A., Wei, H., Pingguan-Murphy, B., Erlandsson, B., Li, X., Lee, W., Hu, J., Wang, L., Xu, F.. Advances in Smartphone-Based Point-of-Care Diagnostics, Proc. IEEE. 2015, 103, 236-247. (Impact Factor in 2016, 9.2)
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 Dou, M.; Dominguez, D. C.; Li, X. J.*; Sanchez, J.; Scott, G. "A versatile PDMS/paper hybrid microfluidic platform for rapid and sensitive infectious diseases diagnosis", Anal. Chem. 2014, 86 (15), 7978-7986. (2016 IF 6.3)


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Shen, F.; Li, X. J.*; Li, P. C. H. "Study of flow behaviors on single-cell manipulation and shear stress reduction in microfluidic chips using CFD simulations",  Biomicrofluidics, 2014, 8, 014109 (1-12).

 * Most cited papers from 2015.



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 Most cited papers!


Li, X. J.*; Li, P. C. H.* "Cytosolic calcium measurement for single-cell drug efficacy and cardiotoxicity evaluations using microfluidic biochips", Can. J. Pure & Appl. Sci. 2014, 8, 2663-2669.


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Zuo, P., Li, X.J.*, Dominguez, D.C., Ye, B.C., "A PDMS /paper /glass hybrid microfluidic biochip integrated with aptamer-functionalized graphene oxide nano-biosensors for one-step multiplexed pathogen detection", Lab Chip. 2013, 13, 3921-3928.


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 Li, Xiujun, Yu zhou, Editor "Microfluidic Devices for Biomedical Applications",  Woodhead Publishing (a part of Elsevier), 2013, 684 Pages. (Book, ISBN 0 85709 697 4;  ISBN-13: 978 0 85709 697 5). Also available from Elsevier Store and  Amazon.


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28. Gao, N.; Li, X. J., Controlled drug delivery using microfluidic devices. In Microfluidic Devices for Biomedical Applications,  Woodhead Publishing: 2013,  167-184. (Book Chapter)   Full Text
27. Benhabib, M.; Li, X. J., Strategies for Conducting Low-Cost Assays in Paper-Based Microfluidic Devices. In Microfluidic Devices for Biomedical Applications, Woodhead Publishing: 2013, 492-526. (Book Chapter)   Full Text

Li, XiuJun.*, Valadez, Alejandra V., Zuo, Peng,  Nie, Zhihong, "Microfluidic 3D cell culture: potential application for tissue-based bioassays", Bioanalysis, 2012, 4(12), 1509-1525.

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Earlier Work


Liu, X.Y., Mwangi, M., Li, X.J., O'Brien, M., Whitesides, G.M., "Paper-Based Piezoresistive MEMS Sensors", Lab Chip. 2011, 11, 2189-2196. 

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23. Liu, X. Y.; Cheng, C. M.; Martinez, A. W.; Mirica, K. A.; Li, X. J.; Phillips, S. T.; Mascarenas, M.; Whitesides, G. M., A Portable Microfluidic Paper-Based Device for Elisa. Proc Ieee Micr Elect 2011, 75-78.   Full Text
22. Liu, X. Y.; O'Brien, M.; Mwangi, M.; Li, X. J.; Whitesides, G. M., Paper-Based Piezoresistive Mems Force Sensors. Proc Ieee Micr Elect 2011, 133-136.   Full Text

Li, X.J., Chen, Y., Li, P.C.H., "Modulation of Multidrug Resistance the Same Single Cancer Cell Selected in a Microfluidic Chip: Intended for Cancer Stem Cell Research", in Cancer Stem Cells- The Cutting Edge, Stanley Shostak (Ed.), InTech, Croatia, 2011, 529-554. (Book Chapter. ISBN: 978-953-307-580-8).
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Liu, P., Li, X.J., Greenspoon, S.A., Scherer, J.R., Mathies, R.A., "Integrated DNA purification, PCR, sample Cleanup, and capillary electrophoresis microchip for forensic human identification", Lab Chip. 2011, 11, 1041-1048.  

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Li, X.J., Chen, Y., Li, P.C.H., "A simple and fast microfluidic approach of same-single-cell analysis (SASCA) for the study of multidrug resistance modulation in cancer cells", Lab Chip, 2011, 11, 1378-1384.

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18. Li, X.J., Nie, Z.H., Cheng, C.M., Goodale, A.B., Whitesides, G.M., "Paper-based electrochemical ELISA", Proc. Micro Total Analysis Systems, 2010, 14, 1487-1489.   Full Text

Li, X.J., Li, P.C.H., "Strategies for the real-time detection of calcium channel events of single cells: recent advances and new possibilities", Expert Rev. Clin. Pharmacol., 2010, 3, 267-280.

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Chen, H., Li, X.J., Wang, L., Li, P.C.H., "A rotating microfluidic array chip for staining assays", Talanta, 2010, 81, 1203-1208. 

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15. Li, X.J., Xue, X., Li, P.C.H., "Real-time quantitative detection of the early event of cytotoxicity of herbal ingredients on single leukemia cells studied in a microfluidic biochip for drug discovery", Integr. Biol., 2009, 1, 90-98.    Full Text
14. Li, X.J., Ling, V., Li, P.C.H., "Same-Single-Cell Analysis for the Study of Drug Efflux Modulation of Multidrug Resistant Cells Using a Microfluidic Chip", Anal. Chem. 2008, 80, 4095-4102.  
Featured as an ACS research profile by Anal. Chem.: 2008, 80, 3951.
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13. Li, X.J., Li, P.C.H., "Studying Contractible Bodies with a Microsensor Based on the Quartz Crystal Resonator", Can. J. Pure & Appl. Sci., 2008, 2, 179-190.   Full Text
12. Li, X.J., Chen, Y., Li, P.C.H., "The microfluidic same-single-cell analysis (SASCA) for medical diagnosis of multi-drug resistance and its inhibition", Proc. Micro Total Analysis Systems, 2008, 12, 1885-1887.   Full Text
11. Li, X.J., Huang, J., Tibbits, G.F., Li, P.C.H., "Real-time monitoring of intracellular calcium dynamic mobilization of a single cardiomyocyte in a microfluidic chip pertaining to drug discovery", Electrophoresis, 2007, 28, 4723-4733.   Full Text
10. Li, X.J., Li, P.C.H., "Contraction study of a single cardiac muscle cell in the microfluidic chip", Methods Mol. Biol., 2006, 321, 199-226.   Full Text
9. Li, X.J., Li, P.C.H., "Microfluidic selection and retention of a single cardiac myocyte, on-chip dye loading, cell contraction by chemical stimulation, and quantitative fluorescent analysis of intracellular calcium", Anal. Chem. 2005, 77(14), 4315-4322.    Full Text
8. Li, P.C.H., Li, X.J., "Microfluidic lab-on- a-chip" in J. Cazes ed. Ewing's Analytical Instrumentation Handbook, 3rd edition, Marcel Dekker, New York, 2005, 581-680. ( Book Chapter. ISBN: 0-8247-5348-8 )   Full Text
7. Jin, W., Li, X.J., Gao, N., "Simultaneous determination of tryptophan and glutathione in individual rat hepatocytes by capillary zone electrophoresis with electrochemical detection at a carbon fiber bundle-Au/Hg dual electrode", Anal. Chem. 2003, 75, 3859-3864.
-M.Sc. thesis work. Wenrui Jin was XL's M.Sc. Senior Supervisor.
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6. Li, X.J., Jin, W., Weng, Q., "Separation and determination of homovanillic acid and vanillylmandelic acid by capillary electrophoresis with electrochemical detection", Anal. Chim. Acta, 2002, 461, 123-130.    Full Text
5. Li, X.J., Jin, W., "Monitoring homovanillic acid and vanillylmandelic acid in human urine by capillary electrophoresis with electrochemical detection", Chin. Chem. Lett., 2002, 13, 874-876.   Full Text
4. Li, X.Z., Bian, X.F., Li, X.J., et al., "Influence of element of Cu on hydrogen content in superheated aluminum melt", Trans. Nonferrous Met. Soc., 2001, 11(3),358-360.   Full Text
3. Li, X.Z., Bian, X.F., Li, X.J., et al., "Ab initio studies of TiB2 and AlB2 in the Al-Ti-B alloy", Acta Metall. Sin., 2001, 37(3), 235-238.   Full Text
2. Zhang, L.X., Hang, H., Wang, Z.H., Li, X.J., "The antioxidant activities of 21 Kinds of Herbals", Chinese Traditional and Herbal Drugs, 2000, 31(8), 609-610.
- Undergraduate thesis work. LiXin Zhang & Hu Hang were XL's undergraduate supervisors.
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1. Zhang, L.X., Hang, H., Wang, Z.H., Li, X.J., "The antioxidant activities of 21 kinds of vegetables by DPPH method", Food Sci., 1999, 11, 21-23.
-Undergraduate thesis work. LiXin Zhang & Hu Hang were XL's undergraduate supervisors.
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